SporeWeb

Bacillus subtilis

Pre-sporulation stage - the vegetative state of B. subtilis cells

t1 50 vegetativestate 50 heatm 50

Graph

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Regulatory network interactions during vegetative growth

Active regulons during commitment to sporulation are indicated by green squares (proteins) or blue hexagons (sigma factors). Positive or negative effects on the transcription of genes (coloured circles) are indicated by connecting blue and red lines, respectively. In the case of Spo0A, a high-threshold effect is represented by thick lines and a low-threshold effect by thin lines. Important sporulation genes indicated as being part of the minimal sporulation set of genes  182 are indicated by thick black rims. Genes have been colour-coded according to their functional category (see legend in the grey vertical bar on the right). More information about specific genes can be accessed by clicking on the coloured circle.

 

 

 

Sporulation cycle of Bacillus subtilis

 

All genes have been colour-coded according to their functional category. Important germination genes that are part of the minimal sporulation set as determined by Galperin and coworkers 182 are indicated by thick black rims.

 

Class

  Antimicrobials
  Biofilm formation
  Cell division and DNA replication
  Cell wall degradation
  Cell wall metabolism
  Cell wall synthesis
  Competence
  DNA protection
  DNA repair
  Metabolism
  Mother cell lysis
  Mother cell metabolism
  Motility and chemotaxis
  Nucleotide biosynthesis
  Phosphorelay
  Resistance
  Respiration
  RNA chaperones
  Rnases
  Sortases
  Spore coat
  Spore coat assembly
  Spore coat maturation
  Spore cortex
  Spore germination
  Spore maturation
  Spore morphogenesis
  Sporulation protein
  Toxins and antitoxins
  Transcriptional regulation
  Translation
  Transport