Bacillus Subtilis

AbrB Starvation – activation of Spo0A

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AbrB during starvation

As Spo0A~P binds to and represses the PabrB promoter 10, the levels of the AbrB repressor are significantly decreased 46. Binding of AbbA to previously produced AbrB protein leads to further inactivation of this repressor 58 causing a derepression of a large subset of genes that is in this way indirectly activated by Spo0A~P.


Sporulation cycle of Bacillus subtilis

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