Bacillus Subtilis

SinR Starvation – activation of Spo0A

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 Starv SinR png

SinR during starvation

As the cells enter stationary phase, the repressor activity of SinR is lifted as levels of activated Spo0A~P increase and allow for binding to the most upstream promoter sequence of the sinI gene 14. Binding of SinI to SinR inactivates the repressor 47 and subsequently derepresses a large subset of genes, including those required for biofilm formation and sporulation 18, 44.


Sporulation cycle of Bacillus subtilis

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