SigE Onset of sporulation – (Stage I - II)
SigE during the onset of sporulation
Under dual control of Spo0A~P and σA the spoIIG locus is transcribed 77, 79 consisting of spoIIGA, sigE (spoIIGB) and sigG (spoIIIG). σE is synthesized in an inactive state called pro-σE and requires both SpoIIGA and forespore-specific SpoIIR for activation 79, 80 (also see the COMMITMENT state). Pro-σE resides in the cytoplasmic membrane where it awaits proteolytic cleavage 81, 82.