SpoVT Completion of engulfment and cortex systhesis
SpoVT during engulfment
The spoVT gene is transcribed under the control of σG in the forespore. Its protein product is known to tetramerize and bind a so far unknown ligand before it can execute its activity as a transcriptional regulator in the forespore 155, 156. It acts by activating or repressing a subset of genes within the σG regulon, as well as by inhibiting the expression of the spoIIIG gene encoding σG 101, 157. The fine-tuning actions of SpoVT on late forespore-specific gene transcription has been described to have a significant effect on the production of proteins involved in the spore germination process and has been mentioned as a source of observed heterogeneity therein 158. This fine-tuning action is enhanced by the interplay with another RNA polymerase-binding modulator of σG-dependent gene expression, YlyA 140.